Sarah Sammons, Co-Leader of Breast Oncology at UMGCCC, shared on LinkedIn:
“ELECTRA (Phase 1b/2, interim Phase 2 data): elacestrant + abemaciclib in ER+/HER2- metastatic breast cancer with active brain metastases, presented at the 2026 SNO/ASCO CNS Metastases Conference.
Both agents cross the BBB, reaching clinically meaningful plasma and CSF concentrations.
Efficacy in the interim analysis (patients with active brain metastases, per BICR):
- Overall RECIST v1.1 (n=21): ORR 14.3%, CBR-24wk 23.8%
- Intracranial RECIST v1.1 (n=16): ORR 12.5%, CBR-24wk 25.0%
- RANO-BM (n=16): ORR 18.8%, CBR-24wk 31.3%
That’s a 2-3 times jump in ORR vs historical endocrine therapy regimens, in a population that often has limited options.
One fatal carotid thrombosis (abemaciclib-related) led to revised eligibility criteria to reduce VTE risk.
Lin N, et al. 2026 SNO/ASCO CNS Metastases Conference, Abstract CLTR-07. NCT05386108”
Title: CLTR-07 ELECTRA: AN OPEN-LABEL, MULTICENTER, PHASE 1B/2 STUDY OF ELACESTRANT IN COMBINATION WITH ABEMACICLIB IN PATIENTS WITH BRAIN METASTASES FROM ER+/HER2– BREAST CANCER
Authors: Nancy U Lin , Milana Bergamino Sirven , Kyung-hun Lee , Timucin Cil , Haythem Ali , Manuel Ruiz Borrego , Jugón Shin , Sercan Aksoy , Mahmut Gumus , Cengiz Karacin , Cristian Villanueva , Eva Ciruelos Gil , José A García-Sáenz , Giuseppe Curigliano , Michaela Palleschi , Annalisa Fontana , Alessandra Fabi , Angela Swampillai , Jee Hung Kim , Sung-Bae Kim , Umut Dimirci , Erika Hamilton , Alessandro Di Sanzo , Faten Koraichi Auriol , Bartomeu Piza Vallespir , Tomer Wasserman , Nuhad Ibrahim
Sarah Sammons was recognized among OncoDaily’s ‘Top 100 Xfluencers in Breast Cancer: Key Opinion Leaders to Follow on X (Twitter) in 2024’, highlighting their contributions to the field of oncology.
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