Rupam Manna, PDT at Narayana Health, shared on X:
“Cisplatin can be life-saving-but it can also permanently damage the delicate outer hair cells of the cochlea.
Key facts:
- High-frequency hearing loss occurs first
- Damage is driven by oxidative stress and mitochondrial injury
- Risk increases with cumulative dose, renal dysfunction, childhood age, and concurrent ototoxic drugs
- Baseline and serial audiometry are essential for early detection
Understanding the biology helps us protect quality of life while delivering effective cancer treatment.”
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