Raffaele Colombo, Director of Medicinal Chemistry at Zymeworks, shared on X:
“MRG007 (CDH17 ADC)
Nice to see PK…but the exposure comment is ridiculous.
Calculated in ng/mL based on Cmax, but MW are very different (150000 vs 435).
In reality exatecan exposure is high (6% of ADC AUC), especially for a DAR4 ADC!
Here replotted (in nM).”
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