Raffaele Colombo, Director of Medicinal Chemistry at Zymeworks, shared on X:
“Narrative review on PK modeling for ADCs
One major oversight is that only a few linkers generate free payload via linker instability. For majority of ADCs, instability releases the intact drug-linker, which reconjugates to plasma thiols (e.g. albumin).”
Title: Pharmacokinetic modeling frameworks for complex antibody-drug conjugates analytes: clinical pharmacology considerations
Authors: Devendra Kumar, Arti Verma, Neerja Trivedi
Read The Full Article in Biochemical Pharmacology.
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