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Raffaele Colombo: Is There a Synergistic Effect Between Enfortumab Vedotin and Pembrolizumab?
Raffaele Colombo/LinkedIn
Aug 8, 2025, 12:00

Raffaele Colombo: Is There a Synergistic Effect Between Enfortumab Vedotin and Pembrolizumab?

Raffaele Colombo, Associate Director of Medicinal Chemistry at Zymeworks, posted on X:

“Is there a synergistic effect between enfortumab vedotin (EV) and pembrolizumab (P) for untreated advanced urothelial carcinoma in clinical setting?

This analysis suggests no! EV+P seems to follow a an independent drug action model with no evidence of synergy.”

Raffaele Colombo

Title: Assessment of synergistic vs. independent drug activity for enfortumab vedotin and pembrolizumab in untreated advanced urothelial carcinoma

Authors: Ryan D. Chow, Ronac Mamtani

Read Full Article.

Raffaele Colombo

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