Could Radiotherapy Help “Cold” Lung Cancer Tumours Respond to Immunotherapy? – Lung Cancer Europe
Lung Cancer Europe shared a post on LinkedIn about a paper by Justin Huang et al. published in Nature Cancer:
“Could radiotherapy help ‘cold’ lung cancer tumours respond to immunotherapy?
A new study in Nature Cancer says it might.
These are tumours that usually don’t respond to immunotherapy – often low PD-L1, low TMB, or Wnt-mutated.
But after a short course of SBRT (targeted radiotherapy), patients saw immune changes that made checkpoint inhibitors more effective – even at distant tumour sites.
This could offer a new way to reach people whose cancers don’t currently respond.”
Nature Cancer, July 2025″
You can read the Full Article on Nature Cancer.
Title: Combination of pembrolizumab and radiotherapy induces systemic antitumor immune responses in immunologically cold non-small cell lung cancer
Author: Justin Huang, Willemijn Theelen, Zineb Belcaid, Mimi Najjar, Daphne van der Geest, Dipika Singh, Christopher Cherry, Archana Balan, James White, Jaime Wehr, Rachel Karchin, Noushin Niknafs, Michel van den Heuvel, Victor Velculescu, Kellie Smith, Paul Baas, Valsamo Anagnostou.
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