Gustavo Viani/sbradioterapia.com.br
Feb 25, 2025, 10:20
Gustavo Viani: SBRT vs. Surgery for Pulmonary Metastases in Colorectal Cancer
Gustavo Viani, Professor of Radiation Oncology at Ribeirão Preto Medical School, shared an article by Byung min Lee, et al. on X:
“SBRT vs. Surgery for Pulmonary Metastases in Colorectal Cancer – What’s the Best Local Therapy?
Objective:
- Compare local control and toxicity of SBRT vs. wedge resection in colorectal pulmonary metastases.
Methods:
- Retrospective study of 404 (528 lesions) treated with SBRT or surgery.
- SBRT doses: 50 Gy/5fx, 48 Gy/4fx, 45 Gy/3fx (Mean BED: 112 Gy).
- Surgery: Wedge resection with R0 margins
Key Results:
- 3-y local control: Surgery 88.6% vs. SBRT 86.7% (p=0.174) → No significant difference!
- Toxicity: Surgery: 8.1% complications (no mortality) | SBRT: 2.8% Grade 3-4 pneumonitis.
- 3-yOS: Surgery 45.3% vs. SBRT 27.9% ( selection bias likely).
Clinical Impact:
- SBRT is a viable alternative to surgery in high-risk.
- Similar local control with toxicity but used in more advanced disease.
Multidisciplinary approach needed to select the best local therapy strategy.”
Stereotactic Ablative Radiotherapy Versus Surgery in Patients with Pulmonary Metastases from Colorectal Cancer.
Authors: Byung min Lee, et al.
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