Aleix Prat: How Preoperative Radiotherapy Shapes Tumor Biology in Early-Stage Breast Cancer
Aleix Prat, Director of the Clínic Barcelona Comprehensive Cancer Center at Hospital Clínic de Barcelona, shared on LinkedIn about recent paper he and colleagues co-authored:
“New publication from Clínic Barcelona Comprehensive Cancer Center!
Proud to share our latest work, led by Carles Gomà, Fara Brasó Maristany, and Meritxell Mollà:
‘Preoperative Radiotherapy-Induced Molecular and Immune Modulation in Early-Stage Breast Cancer: Results from the YOUNGSTER Trial’
In this exploratory trial, we investigated in 20 patients how preoperative radiotherapy (RT boost, 5 × 2.67 Gy/fraction) shapes tumor biology in early-stage breast cancer.
What we found: Days after RT: Sharp drop in tumor proliferation (gene expression, PAM50 proliferation score, Ki67)
Weeks after RT: Strong adaptive immune activation, with increased HER2DX B-cell/Ig gene signatures. Sustained DNA damage and macrophage infiltration. Potential for RT to act as an immune primer, paving the way for RT–immunotherapy, RT–chemotherapy, or even triple-modality combinations.
These results highlight that RT does more than control the tumor locally, it can trigger systemic biological effects with therapeutic implications.
A huge thank you to all co-authors, collaborators, and patients who made this possible.”
Title: Preoperative Radiotherapy-Induced Molecular and Immune Modulation in Early-Stage Breast Cancer: Results from the YOUNGSTER Trial
Authors: Carles Gomà, Meritxell Mollà, Gabriela Oses, Esther Sanfeliu, Adela Rodríguez-Hernández, Blanca González-Farré, Patricia Galván, Valeria Sirenko, Oleguer Castillo, Paula Blasco, Alba Llop-Guevara, Violeta Serra, Sergi Ganau, Belén Úbeda, Xavier Bargalló, Carla Cases, Artur Latorre-Musoll, Olga Martínez-Sáez, Isabel Garcia-Fructuoso, Raquel Gómez-Bravo, Francesco Schettini, Barbara Adamo, Tomás Pascual, Maria Vidal, Montserrat Muñoz, Maria Laplana, Isaac Cebrecos, Eduard Mension, Aleix Prat, Fara Brasó-Maristany
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