Science

Patrick Hwu

Feb 24, 2025, 09:47

Patrick Hwu: How can we prevent T cell exhaustion?

Patrick Hwu, President and CEO of Moffitt Cancer Center, shared an article by Shijun Ma, et al. on LinkedIn:

“T cells in the tumor microenvironment can become exhausted, limiting their ability to kill cancer cells.

How can we prevent T cell exhaustion?

In a recent study, Ma et al found that the protein P4HA1 accumulated in activated CD8 T cells, interfering with mitochondrial function and promoting T cell exhaustion. Targeting P4HA1 improved T cell expansion, decreased exhaustion and improved antitumor responses in preclinical models.

This represents a promising approach to one day enhance T cell therapy in patients.

Here’s a link to the full study.”

Targeting P4HA1 promotes CD8+ T cell progenitor expansion toward immune memory and systemic anti-tumor immunity.

Authors: Shijun Ma, et al.

Patrick Hwu: How can we prevent T cell exhaustion?

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