Pashtoon Kasi, Medical Director of GI Medical Oncology at City of Hope Orange County, shared on LinkedIn:
“Today in Nature Medicine.
More on immunotherapy (BOT/BAL) in the neoadjuvant setting. Corroboration of our NEST trial.
UNICORN reports 100% DFS as well in pMMR colorectal cancer.”
Title: Neoadjuvant botensilimab with or without balstilimab in pMMR and dMMR colon cancer: the phase 2 UNICORN trial
Authors: Filippo Ghelardi, Margherita Ambrosini, Alessandra Raimondi, Andrei Tyshevich, Federica Palermo, Francesca Bergamo, Vincenzo Nasca, Paolo Manca, Ilaria Mulas, Lisa Derosa, Gina Brown, Claudia Chiodoni, Massimo Di Maio, Samantha Di Donato, Anna Chiaramonte, Lorenzo Castagnoli, Stephanie Ni, Darryl Nousome, Erik Spickard, Antony Tin, Robert Lentz, Adham Jurdi, Giovanna Sabella, Daniele Spada, Stefano Tamberi, Alessandro Passardi, Federica Morano, Emiliano Tamburini, Chiara Rossi, Luca Azzolin, Francesco Cambuli, Antonia Martinetti, Elisa Sottotetti, Andrew Allan Almonte, Valerio Iebba, Chiara Ratti, Riccardo Cerantola, Özlem Kutlu, Eleonora Cristarella, Serenella M. Pupa, Cecilia Villa, Eleonora Perissinotto, Margherita Galassi, Andrea Barina, Fabrizio Vittadello, Marcello Guaglio, Gianluca Baiocchi, Andrea Sartore-Bianchi, Riccardo Rosati, Chiara Cremolini, Isacco Montroni, Sara Lonardi, Andrea Sottoriva, Filippo Pietrantonio
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Title: Neoadjuvant Botensilimab/Balstilimab for Localized Mismatch Repair–Proficient and –Deficient Colon Cancer: Results of the NEST Phase II Clinical Trial
Authors: Manish A. Shah, Erika Hissong, Mehraneh D. Jafari, Pashtoon Murtaza Kasi, Maider Astorkia, Sahrish Khan, Casey Owens, Zhengming Chen, Heather Yeo, Fabio Socciarelli, Sandipto Sarkar, Alana Nguyen, Despina Siolas, Allyson Ocean, Kelly Garrett, Lea Lowenfeld, Alessio Pigazzi, Preethi Guniganti, Sanjay Patel, Doron Betel, Manuel Hidalgo
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