Orly Leiva, Interventional Cardiology Fellow, Assistant Professor at University of Kentucky College of Medicine, shared on LinkedIn:
“Proud to share our latest research paper in International Cardio-Oncology Society on high-output HF in PV/ET.
High-output HF is classically associated with MPNs.
Our prior work in MF demonstrated an association with elevated estimated cardiac output on echocardiography with worse outcomes.
However, ET and PV patients have different pathophysiology and clinical characteristics.
In this study we characterized patients with ET or PV by echocardiographic cardiac output and pulmonary artery pressures (both normal, elevated cardiac output alone, elevated PASP alone or elevated cardiac index and PASP (high-output HF)).
We demonstrated an association between increased risk of ET or PV progression to MF or leukemia among those with HOHF and elevated PASP alone compared to normal hemodynamics.
Additionally, we demonstrated a correlation between echocardiographic cardiac output and driver mutation variant allele burden.”
Title: Impact of echocardiographic hemodynamics on outcomes among patients with polycythemia vera or essential thrombocythemia
Authors: Orly Leiva, Steven Soo, Olivia C. Liu, Victor You and Gabriela Hobbs
Other articles about International Cardio-Oncology Society and Heart failure on OncoDaily.
