Nivedeta Krishna Kumar, Doctoral Student at University of Nebraska Medical Center, shared on LinkedIn:
“A little late to this side, but, excited to share our latest publication in Cell Reports: ‘SLC22A3/OCT3 Drives Serotonin-Mediated Stemness in Pancreatic Cancer’.
In this study, we identify SLC22A3/OCT3 as a critical regulator of pancreatic cancer stem cells, where it facilitates serotonin transport and promotes stemness through histone serotonylation-mediated epigenetic reprogramming. Targeting SLC22A3 significantly reduced cancer stem cell properties and tumor growth, highlighting a promising therapeutic avenue for pancreatic cancer.
A huge thank you to my mentor Moorthy P. Ponnusamy, collaborators, and co-authors for their invaluable contributions to this work.”
Title: SLC22A3/OCT3 drives serotonin-mediated stemness in pancreatic cancer
Authors: Nivedeta Krishna Kumar, Venkatesh Varadharaj, Neelanjana Gayen, Annant Bir Kaur, Kirtana Arikath, Ashu Shah, Poompozhil Mathivanan, Palanisamy Nallasamy, Zahraa Wajih Alsafwani, Bhuvaneshwari Seshadri, Pratima Raut, Sanchita Rauth, Jimmie Persinger, Sandipan Brahma, Micah Schott, Rebecca E. Oberley-Deegan, Geoffrey A. Talmon, Jesse L. Cox, Surinder K. Batra, Moorthy P. Ponnusamy
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