Science

Nikolas Naleid: Excited to share our systematic review on pembrolizumab safety in GI cancers

Nikolas Naleid/X

Jan 26, 2025, 21:58

Nikolas Naleid: Excited to share our systematic review on pembrolizumab safety in GI cancers

Nikolas Naleid, Internal Medicine resident at Case Western Reserve/UH Cleveland Medical Center, shared a recent article by him and colleagues on X:

“Excited to share our systematic review on pembrolizumab safety in GI cancers was published in Biomedicines MDPI.

Overview:

25 studies, 3101 patients (median age 62, 30.2% F).
Cancer types: CRC (12%), EG (46%), HCC (24%), other GI (18%)

Decreased irAE rates:

Discontinuation: 6.8%
Grade ≥3: hepatitis 3.6%, pneumonitis 0.8%, colitis 0.7%
Death: 0.9%”

“Toxicity Associated with Pembrolizumab Monotherapy in Patients with Gastrointestinal Cancers: A Systematic Review of Clinical Trials“

Authors: Nikolas Naleid, Amit Mahipal and Sakti Chakrabarti

Nikolas Naleid

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