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Arndt Vogel: NEOPAN Shows PFS Benefit but No OS Gain with FOLFIRINOX in Locally Advanced PDAC
May 26, 2025, 18:57

Arndt Vogel: NEOPAN Shows PFS Benefit but No OS Gain with FOLFIRINOX in Locally Advanced PDAC

Arndt Vogel, Managing Senior Consultant and a Professor in the Department of Gastroenterology, Hepatology, and Endocrinology at Hannover Medical School, shared a post on X about a paper by Michel Ducreux et al. published in the Journal of Clinical Oncology:

“PRODIGE 29-UCGI 26 (NEOPAN): Phase III Randomized Trial Comparing FOLFIRINOX or Gemcitabine in Locally Advanced PDAC:
  • mPFS 9.7 vs 7.7 mo
  • mOS 15.5 vs 15.5 mo
  • PFS improved, but more toxicity and no OS benefit. Sufficient data to favour the triplet.”

Title: PRODIGE 29-UCGI 26 (NEOPAN): A Phase III Randomized Trial Comparing Chemotherapy With FOLFIRINOX or Gemcitabine in Locally Advanced Pancreatic Carcinoma

Authors: Michel Ducreux, Romain Desgrippes, Yves Rinaldi, Frédéric Di Fiore, Rosine Guimbaud, Ludovic Evesque, Jean-Baptiste Bachet, Pierre Vanelslander, Thierry Lecomte, Olivier Capitain, Aurélie Parzy, Marion Bolliet, Pierre-Luc Etienne, Julien Forestier, Farid El Hajbi, Anne-Laure Bignon, Valérie Lebrun-Ly, Nicolas De Sousa Carvalho, Matthieu Texier, Olivier Bouche.

Arndt Vogel: NEOPAN Shows PFS Benefit but No OS Gain with FOLFIRINOX in Locally Advanced PDAC

You can read the Full Article in the Journal of Clinical Oncology.

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