Nelson Dusetti, INSERM Research Director at CRCM and Institut Paoli-Calmettes, shared on LinkedIn:
“November is Pancreatic Cancer Awareness Month, and I am very happy to share new research from Marseille!
Our colleagues at the CRCM – Centre de Recherche en Cancérologie de Marseille have just released an important study on bioRxiv:
‘The methionine cycle sustains the mesenchymal phenotype of tumor cells and drives pancreatic cancer progression.’
This work provides new insights into how pancreatic cancer cells adapt their metabolism to acquire and maintain an aggressive, mesenchymal phenotype associated with tumor progression and metastasis.
The authors demonstrate that the methionine cycle, particularly the enzyme SAHH, plays a key role in sustaining this aggressive cellular state. Targeting SAHH disrupts antioxidant defenses and calcium homeostasis, reduces the invasive properties of tumor cells, and limits tumor growth and liver metastasis formation in preclinical models.
These findings identify a metabolic vulnerability that could open new therapeutic perspectives for targeting some of the most aggressive forms of pancreatic cancer.
Warm congratulations to Sophie Vasseur, Fabienne Guillaumond, Emilie Jaune Pons, Georgios Efthymiou, and all the co-authors for this excellent collaborative work!
I am particularly happy and proud that our team had the opportunity to contribute to this study.
On a more personal note, I have dedicated 35 years, essentially my entire scientific career, to pancreatic cancer research. One of my greatest satisfactions today is seeing a new generation of scientists and emerging research teams at our center in Marseille dedicating their energy, creativity, and enthusiasm to understanding this devastating disease.
Scientific progress takes time. It builds on years of research, collaboration, shared knowledge, and the commitment of successive generations of scientists.
Seeing this scientific community continue to grow and renew itself here in Marseille makes me particularly happy.
The next generation is already here, and the future of pancreatic cancer research is in very good hands!
Congratulations again to everyone involved, and thank you for contributing to this collective scientific effort.”
Title: The methionine cycle sustains the mesenchymal phenotype of tumor cells and drives PDA progression
Authors: Sophie Vasseur, Fabienne Guillaumond, Metay Elodie, Quentin Da-Costa, Pascal Finetti, François Bertucci, Richard Tomasini, Nelson J. Dusetti, Émilie Mamessier, Georgios Efthymiou, Emilie Jaune-Pons, Victoire Gouirand, Sarah Simba Tubiana, Cindy Neuzillet, Eugenie Lohmann, Sadia Djefaflia-Beloribi, Pierre Grenot
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