Robert Orlowski, Florence Maude Thomas Cancer Research Professor at the University of Texas MD Anderson Cancer Center, shared on X:
“Myeloma Paper of the Day:
Home grown autologous fully-human 3rd-generation CD20-directed CAR-T containing CD28 & 41BB costimulatory domains shows CR/VGPR rate of 80% in heavily pre-treated patients w/ low CRS rate & 2-year PFS of 68.6% & OS of 90%.”
Title: CD20-directed Autologous CAR T-cell Therapy for Waldenström Macroglobulinemia
Authors: Mazyar Shadman, Mary W. Redman, Sang Yun Lee, Kelsey K. Baker, Dong Hoon Lee, David Hong, Zhao Qian, Cecilia C. S. Yeung, Bruce J. Dezube, Manuel Litchman, Cathee Till, Xiaoling Song, Folashade Otegbeye, Aude G. Chapuis, Ryan D. Cassaday, Edus H. Warren, Filippo Milano, Jordan Gauthier, Alexandre V. Hirayama, Mary L. Kwok, Lorenzo Iovino, Chaitra S. Ujjani, David G. Maloney, Ajay K. Gopal, Brian G. Till
You can read the full article on Blood.
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