Robert Orlowski, Florence Maude Thomas Cancer Research Professor at the University of Texas MD Anderson Cancer Center, shared on X:
“Myeloma Paper of the Day:
African genetic similarity assoc w/ reduced inflammation/enhanced adaptive immunity, enrichment late T-effectors driven by rare cytotoxic CD4⁺s; expansion of late-differentiated adaptive NKs w/ high cytotoxic GNLY, GZMH.”
Title: African Genetic Similarity Is Associated with Reduced Inflammation and Enhanced Adaptive Immunity in Multiple Myeloma
Authors: William C Pilcher, Hongwei Tang, Katherine Ferguson, Steven M Foltz, Marina E Michaud, Sarthak Satpathy, Nishi Nilesh Shah, Yuxin Jin, Denis Ohlstrom, Mojtaba Bakhtiari, Chaitanya R Acharya, Immune Atlas Consortium, Alexander M Gout, Jonathan Keats, Madhav V. Dhodapkar, David E. Avigan, Ravi Vij, Shaji K. Kumar, Hearn Jay Cho, Ioannis S Vlachos, Li Ding, Sacha Gnjatic, Craig Emmitt Cole, Ajay K. Nooka, Sagar Lonial, John Carpten, George Mulligan, Linda B Baughn, Manoj Bhasin
You can read the full article on Blood.

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