Robert Orlowski, Florence Maude Thomas Cancer Research Professor at the University of Texas MD Anderson Cancer Center, shared on X:
“Myeloma Paper of the Day:
USP8 controls B and myeloma cell proteostasis; catalytically inactive USP8 leads to accumulation of proteins w/ mixed ubiquitin/NEDD8 chains indicative of proteotoxic stress; knockdown reduced survival via lysosomal dysfxn.”
Title: USP8 controls proteostasis pathways in B cells and multiple myeloma
Authors: Almut Dufner, Fabien Thery, Gianni Monaco, Jelena Lazarevic, Oliver Gorka, Nina Chevalier, Marta Campos Alonso, Maximilian Frosch, Gerbrand J. van der Heden van Noort, Kira Allmeroth, Marco Prinz, Olaf Groß, Huib Ovaa, Paul P. Geurink, Wolfgang W. Schamel, Martin S. Denzel, Vigo Heissmeyer, Benedikt Jacobs, Mirle Schemionek, Francis Impens, Heiko Bruns, Klaus-Peter Knobeloch
You can read the full article on Leukemia.
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