Robert Orlowski, Deputy Chair of Lymphoma/Myeloma, Vice Chair of MM Research, and Florence Maude Thomas Cancer Research Professor at the University of Texas MD Anderson Cancer Center, shared a post on X:
“Myeloma Paper of the Day:
mTOR activity and CD8+ T cell metabolic reprogramming are impaired (decreased activation-induced glycolysis and mitochondrial glutamine oxidation) under hypoxia in myeloma bone marrow, thus reducing BCMAxCD3 bispecific activity.”
Title: mTOR activity and metabolic reprogramming of CD8+ T cells is impaired under hypoxia and within the multiple myeloma bone marrow
Authors: Taylor Fulton-Ward, Nancy Gudgeon, Isaac Thirlwell, Emma Louise Bishop, Bryan Marzullo, Hannah Victoria Giles, Graham McIlroy, Paul Ferguson, Bhuvan Kishore, Kate Rogers, Nuri Nuri Alfasi, Timothy Wong, Satnam Aytain, Daniel A. Tennant, Guy Pratt, Sarah Dimeloe
You can read the Full Article in Blood Advances.
You can find more posts featuring Robert Orlowski on OncoDaily.
