Myeloma Paper of the Day, December 29th, suggested by Robert Orlowski
Robert Orlowski shared a post on X:
“Myeloma Paper of the Day: BCMA-directed CAR T-cell therapy in myeloma patients with CNS involvement gives ORR of 80%, VGPR or better 70%, and CNS response 100%, median OS and PFS of 13.3 and 6.3 months, suggesting consideration for post-CART maintenance.”
BCMA-directed CAR T-cell Therapy in patients with multiple myeloma and CNS involvement
Authors: Mahmoud R. Gaballa, Omar Castaneda Puglianini, Adam D. Cohen, Dan T Vogl, Alfred Chung, Christopher J Ferreri, Peter M Voorhees, Doris K Hansen, Krina K. Patel.
More posts featuring Robert Orlowski.
Robert Orlowski, M.D., Ph.D., holds multiple positions at The University of Texas MD Anderson Cancer Center, including Chairman, Ad Interim Director of Myeloma, and Professor of Medicine in the Departments of Lymphoma/Myeloma and Experimental Therapeutics within the Division of Cancer Medicine.
Additionally, he chairs the SWOG Barlogie/Salmon Myeloma Committee, which is part of the National Clinical Trials Network, dedicated to advancing new therapies and understanding the biology of myeloma.
Dr. Orlowski’s expertise lies in both clinical practice and scientific research, with a particular focus on translating laboratory discoveries into effective treatments for patients. He investigates drug resistance mechanisms in myeloma and seeks to identify predictive biomarkers for treatment response.
Notably, his past contributions include leadership roles in developing proteasome inhibitors like bortezomib and carfilzomib, as well as monoclonal antibodies such as daratumumab and elotuzumab.
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