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New Study Shows Extrachromosomal DNA Fuels Therapy Adaptation in MYCN-Amplified Cancers
Photo: Depositphotos
Aug 14, 2025, 09:36

New Study Shows Extrachromosomal DNA Fuels Therapy Adaptation in MYCN-Amplified Cancers

Elizabeth McKenna, Executive Editor of Cancer Discovery, shared a post on X about recent paper by Giulia Montuori et al., published in Cancer Discovery.

“Now online in Cancer Discovery: Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers – by Giulia Montuori, Fengyu Tu, Jan Dörr, and colleagues.”

Title: Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers

Authors: Giulia Montuori, Fengyu Tu, Di Qin, Rachel Schmargon, Elias Rodriguez-Fos, Konstantin Helmsauer, Hui Hui, Susmita Mandal, Karin Purshouse, Lara Fankhänel, Bartolomeo Bosco, Bastiaan Spanjaard, Hannah Seyboldt, Laura Grunewald, Matthias Jürgen Schmitt, Dennis Gürgen, Viktoria Buck, Mathias T. Rosenfeldt, Frank P.B. Dubois, Simon Schallenberg, Annika Lehmann, Jessica Theißen, Sabine Taschner-Mandl, Arend Koch, Patrick Hundsdoerfer, Annette Künkele, Angelika Eggert, Matthias Fischer, Gaetano Gargiulo, Teresa G. Krieger, Lukas Chavez, Fabian Coscia, Benjamin Werner, Weini Huang, Anton G. Henssen, Jan R. Dörr

Read The Full Article.

New Study Shows Extrachromosomal DNA Fuels Therapy Adaptation in MYCN-Amplified Cancers

More posts featuring Elizabeth McKenna on OncoDaily.

Angelika Eggert Annette Künkele Annika Lehmann Anton G. Henssen Arend Koch Bartolomeo Bosco Bastiaan Spanjaard Benjamin Werner cancer Dennis Gürgen Di Qin Elias Rodriguez-Fos Elizabeth McKenna Fabian Coscia Fengyu Tu Frank P.B. Dubois Gaetano Gargiulo Giulia Montuori Hannah Seyboldt Hui Hui Jan R. Dörr Jessica Theißen Karin Purshouse Konstantin Helmsauer Lara Fankhänel Laura Grunewald Lukas Chavez Mathias T. Rosenfeldt Matthias Fischer Matthias Jürgen Schmitt OncoDaily Oncology Patrick Hundsdoerfer Rachel Schmargon Sabine Taschner-Mandl Simon Schallenberg Susmita Mandal Teresa G. Krieger Viktoria Buck Weini Huang
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