Matthew Oser: An Exciting New Potential Therapeutic Strategy for G1-S Checkpoint-Compromised Cancers
Matthew Oser, Associate Professor of Medicine at Dana-Farber Cancer Institute and at Harvard Medical School, shared a post on X about a paper he co-authored with colleagues published in Nature:
“Thrilled to share our new work published in Nature. We report an exciting new potential therapeutic strategy with a fascinating mechanism of action for cancers with a compromised G1–S cell cycle checkpoint, including SCLC.
This study was led by my highly talented postdoctoral fellow, Shilpa Singh, and was an outstanding collaboration with Circle Pharma and Deepak Nijhawan’s lab at UTSW.’
Title: Targeting G1–S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors
Authors: Shilpa Singh, Catherine E. Gleason, Min Fang, Yasmin N. Laimon, Vishal Khivansara, Shanhai Xie, Yavuz T. Durmaz, Aniruddha Sarkar, Kenneth Ngo, Varunika Savla, Yixiang Li, Muhannad Abu-Remaileh, Xinyue Li, Marie-Anais Locquet, Bishma Tuladhar, Ranya Odeh, Frances Hamkins-Indik, Daphne He, Miles W. Membreno, Meisam Nosrati, Nathan N. Gushwa, Siegfried S. F. Leung, Breena Fraga-Walton, Luis Hernandez, Miguel P. Baldomero, Bryan M. Lent, David Spellmeyer, Joshua F. Luna, Dalena Hoang, Yuliana Gritsenko, Manesh Chand, Megan K. DeMart, Sammy Metobo, Chinmay Bhatt, Justin A. Shapiro, Kai Yang, Nathan J. Dupper, Andrew T. Bockus, Jinshu Fang, Ramesh Bambal, Peadar Cremin, John G. Doench, James B. Aggen, Li-Fen Liu, Bernard Levin, Evelyn W. Wang, Iolanda Vendrell, Roman Fischer, Benedikt Kessler, Prafulla C. Gokhale, Sabina Signoretti, Alexander Spektor, Constantine Kreatsoulas, Marie Evangelista, Rajinder Singh, David J. Earp, Deepak Nijhawan, Pablo D. Garcia, Matthew G. Oser
You can read the Full Article on Nature.
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