Maryam Lustberg, Director of the Center for Breast Cancer at Yale University School of Medicine, shared on LinkedIn:
“In the coming weeks, I will be highlighting the key research studies led by oncologists as part of multisciplianary teams focused on symptom management related to endocrine therapy for breast cancer.
These studies were conducted as early as over a decade ago, funded by National Cancer Institute (NCI) and ran by the major cancer cooperative trials. As the co chair of Symptom Intervention for Alliance for Clinical Trials in Oncology, I feel strongly that these contributions need to be seen AND utilized in routine practice.
As new focus rightfully is being given to menopause concerns of individuals after cancer, it is important to appraise the existing large body of data for symptom managment.
As a community of oncologists and researchers, we have cared deeply about this issue.”
Title: Management of Aromatase Inhibitor–Induced Musculoskeletal Symptoms
Authors: Arjun Gupta, N. Lynn Henry, Charles L. Loprinzi.
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“Based on phase 3 NCI cooperative studies SWOG Cancer Research Network with acupuncture and duloxetine”
Title: Randomized, Multicenter, Placebo-Controlled Clinical Trial of Duloxetine Versus Placebo for Aromatase Inhibitor–Associated Arthralgias in Early-Stage Breast Cancer: SWOG S1202
Authors: N. Lynn Henry, Joseph M. Unger, Anne F. Schott, Louis Fehrenbacher, Patrick J. Flynn, Debra M. Prow, Carl W. Sharer, Gary V. Burton, Charles S. Kuzma, Anna Moseley, Danika L. Lew, Michael J. Fisch, Carol M. Moinpour, Dawn L. Hershman, James L. Wade.
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Title: Comparison of Acupuncture vs Sham Acupuncture or Waiting List Control in the Treatment of Aromatase Inhibitor-Related Joint Pain: A Randomized Clinical Trial
Authors: Dawn L Hershman, Joseph M Unger, Heather Greenlee, Jillian Capodice, Danika L Lew, Amy Darke, Lori M Minasian, Michael J Fisch, N Lynn Henry, Katherine D Crew.
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“Don’t forget AI rotation or switch to tamoxifen for the very symptomatic after a 4-6 week hold.
Movement and stretching also helpful.”
Title: Exercise adherence in a randomized trial of exercise on aromatase inhibitor arthralgias in breast cancer survivors: The Hormones and Physical Exercise (HOPE) Study
Authors: Hannah Arem, Mia Sorkin, Brenda Cartmel, Martha Fiellin, Scott Capozza, Maura Harrigan, Elizabeth Ercolano, Yang Zhou, Tara Sanft, Cary Gross, Kathryn Schmitz, Tuhina Neogi, Dawn Hershman, Jennifer Ligibel, Melinda L Irwin.
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