Magda Sznurkowska, Group Leader at University of Basel, shared on LinkedIn:
“Very happy to see our work now published in Cancer Discovery AACR Journals!
In this study, we show that metastatic environments do more than simply host disseminated cancer cells: they can profoundly shape cancer cell behaviour and influence subsequent metastatic spread, including metastasis-to-metastasis dissemination.
Importantly, we find that breast cancer cells metastasising to the liver undergo a distinct metabolic reprogramming compared with cells growing in the lung.
This provides a mechanistic explanation for the particularly aggressive course associated with liver metastasis and highlights how the organ in which a metastasis develops can shape subsequent disease progression.
We believe this is an important paradigm in triple-negative breast cancer, where visceral metastatic disease is common.
This project has been an inspiration for many of the questions and ideas that I am now excited to pursue in my own lab!
A big thank you to all our great collaborators who made this work possible, and to ETH Zürich and Marie Skłodowska-Curie Actions, European Association for Cancer Research (EACR) , EMBO for supporting my postdoctoral research.
And a very special thank you to Nicola Aceto for building this project together, for the many discussions throughout the process, and for creating such a stimulating environment in which this project could develop!”
Title: The liver niche accelerates, while the lung niche restrains secondary spread of breast cancer
Authors: Magdalena K. Sznurkowska, Francesc Castro-Giner, Irene D’Anna, Ilona Krol, Yongzhan Zhang, Lauren L. Ozimski, Massimo Saini, Jianwen Zhou, Simran Asawa, David Gremmelspacher, Alexander Ring, Karin Strittmatter, Fabienne Dominique. Schwab, Yu Wei Zhang, Selina Budinjas, Marko Vujanovic, Zacharias Kontarakis, Giada Pontecorvi, Francesca Albrecht, Kirsten D. Mertz, Gaël Auray, Claudio Giachino, Verdon Taylor, Ana Gvozdenovic, Werner J. Kovacs, Ilaria Malanchi, Heike Frauchiger-Heuer, Andreas Wicki, Marcus Vetter, Matteo Ligorio, Nicola Aceto
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