Lukas Braun, Postdoctoral Scientist at DKFZ/DKTK, shared on LinkedIn:
“New clinical trial publication in Nature Communications!
I am happy to share our latest work: ՛Extracorporeal photopheresis for the treatment of steroid-refractory immune-related adverse events from immune checkpoint inhibitor therapy: a multi-center phase Ib/II clinical trial․՛
Immune checkpoint inhibitors (ICI) have transformed cancer care, but severe immune-related adverse events (irAEs) often force treatment interruption and high-dose steroids, which can blunt anti-tumor immunity.
When steroids fail, patients urgently need second-line options that are both safe and effective.
In our multi-center phase Ib/II ECIR trial, led from the University Medical Center Freiburg, we tested extracorporeal photopheresis (ECP) in 30 patients with steroid-refractory irAEs.
The results position ECP as a promising, well-tolerated treatment for steroid-refractory irAEs:
- No ECP-related serious adverse events
- 96.3% overall response rate, with a median response time of 7 days
- 100% overall response rate in ICI-colitis patients
- Steroids reduced in all patients
- No signs of impaired tumor control
A huge Thank You to Robert Zeiser, Petya Apostolova, Roxane Riemer and all co-authors, partner centers, the clinical teams and patients.”
Title: Extracorporeal photopheresis for the treatment of steroid-refractory immune related adverse events from immune checkpoint inhibitor therapy: a multi-center phase Ib/II clinical trial
Authors: Roxane Riemer, Lukas M. Braun, Sophie Giesler, David Rafei-Shamsabadi, Sebastian Haferkamp, Alina Hartmann, Wolfgang Melchinger, Matthias Weiss, Stefanie Birth, Ulrike Philipp, Inga Gebhard, Carsten Schwänen, James A. Hutchinson, Nikolaos Karantzelis, Till Wallrabenstein, Theresa Lowinus, Niklas Brehm, Justyna Rawluk, Dietmar Pfeifer, Natascha Osswald, Peter Bronsert, Manuel Rogg, Grigor Andreev, Melanie Boerries, Maximilian Lammer, Van Anh Nguyen, Matthias Schmuth, Natalie Köhler, Justus Duyster, Gabriele Ihorst, Philip Keye, Susana Minguet, Dirk Schadendorf, Selma Ugurel, Robert Thimme, Peter Hasselblatt, Erika L. Pearce, Burkhard Becher, Carolin Funke-Lorenz, Florian Scherer, Bertram Bengsch, Christoph Schell, Jan-Malte Placke, Frank Meiss, Petya Apostolova, Robert Zeiser
Other articles about irAEs on OncoDaily.