Joseph Steward, Medical and Scientific Writer- Oncology, Genomics and NGS methods, Gene and Cell Therapies at Freelance, shared on LinkedIn:
“We characterize the spatiotemporal dynamics of the tumor microenvironment (TME) in bladder cancer (BLCA) samples before and after neoadjuvant immunotherapy in a multicenter real-world cohort (n = 606).
We identify two distinct differentiation outcomes in BLCA epithelial cells: sensitivity and resistance to immunotherapy.
Additionally, we identify SERPINH1 as a common target of acquired immunotherapy resistance in BLCA. Furthermore, we characterize an immunotherapy-induced tumor-myeloid barrier, which leads to an excluded immune phenotype and immunotherapy resistance. Finally, we identify T cell terminal exhaustion and a senescent inflammatory cancer-associated fibroblast phenotype as key factors contributing to immunotherapy resistance.
Collectively, we reveal the dynamic phenotypic evolution of the TME in BLCA during neoadjuvant immunotherapy and identify the characteristics of residual lesions after immunotherapy.
These findings enrich our understanding of immunotherapy resistance in BLCA and contribute to developing combination therapies to improve patient prognosis.”
Title: Spatiotemporal dynamic evolution of the tumor microenvironment during neoadjuvant immunotherapy for bladder cancer
Authors: Jiao Hu, Yifan Liu, Minfeng Chen, Jiantu Ou, Tongchen He, Jinhui Liu, Minghui Hu, Bohan Zhou, Huihuang Li, Luzhe Yan, Jiatong Xiao, Zhenyu Nie, Zhiyong Cai, Peihua Liu, Dingshan Deng, Yunbo He, Benyi Fan, Zhenyu Ou, Ruizhe Wang, Guanghui Gong, Xiao Guan, Shiyu Tong, Yangle Li, Wei He, Zefu Liu, Yuanqing Dai, Bolong Liu, Xiaogen Kuang, Tao Guo, Lunquan Sun, Xiaohua Yao, Junhao Yu, Hengyun Wang, Jinbo Chen, Xiongbing Zu
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