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Jordan Gauthier/fredhutch.org

Aug 14, 2025, 16:27

Study Lead by Jordan Gauthier Finds How ICIs Affect CAR T-Cell Function and the TME in PMBCL

Jordan Gauthier, Associate Professor at Fred Hutch and the University of Washington, shared a post on X about an article published on American Journal of Hematology:

“I was lucky to lead this CIBMTR analysis just published in American Journal of Hematology.

Findings:

CD19 CAR T-cell therapy leads to high rates of durable responses in patients with primary mediastinal large B-cell lymphoma (PMBCL): ORR 79% CRR 68% 2-year PFS 58.6%. Outcomes may be superior compared to other LBCL subtypes.
We observed significantly lower relapse rates in patients exposed to immune checkpoint inhibitors prior to CAR T-cell therapy with
50% absolute reduction in relapse incidence in ICI-exposed (2-year cumulative incidence of relapse: 21.7%) compared to ICI-naive patients (41.6%).
Prior ICI exposure was not associated with higher rates or severity of early toxicities such as cytokine release syndrome and neurotoxicity.

More data needed to better characterize how ICIs impact CAR T-cell function and TME in patients with PMBCL.

Thanks to all collaborators and co-authors Mazyar Shadman, Fred Hutch Cancer Center, Natalie Grover, Brad Haverkos, Marcos de Lima, Adriana Malone, Laurie K Pearson, Anna Sureda, Kitsada Wudhikarn, Sam Yamshon + others not on X.

Special thanks to Mehdi Hamadani, Medical College of Wisconsin and Senior Author Dr. Alex Herrera, City of Hope for their guidance and for putting up with me!

Please share with your network if you learnt something with this post.”

Jordan Gauthier

Title: CD19 CAR T-Cell Therapy for Primary Mediastinal Large B-Cell Lymphoma: A CYBMTR Analysis

Authors: Jordan Gauthier, Kwang W. Ahn, Jinalben Patel, Qinghua Lian, Sherif Badawy, Mitchell S. Cairo, Julio Delgado, Natalie Grover, Bradley Haverkos, Marcos de Lima, Adriana Malone, Alberto Mussetti, Yago Nieto, Attaphol Pawarode, Laurie Pearson, Melhem Solh, Anna Sureda, Aung M. Tun, Kitsada Wudhikarn, Samuel Yamshon, Mazyar Shadman, Cameron J. Turtle, Mehdi Hamadani, Alex F. Herrera

Read The Full Article.

Study Lead by Jordan Gauthier Finds How ICIs Affect CAR T-Cell Function and the TME in PMBCL

More posts featuring Jordan Gauthier on OncoDaily.

Adriana Malone Alberto Mussetti Alex F. Herrera American Journal of Hematology Anna Sureda Attaphol Pawarode Aung M. Tun Bradley Haverkos Cameron J. Turtle CIBMTR Jinalben Patel Jordan Gauthier Julio Delgado Kitsada Wudhikarn Kwang W. Ahn Laurie Pearson Marcos de Lima Mazyar Shadman Mehdi Hamadani Melhem Solh Mitchell S. Cairo Natalie Grover OncoDaily Oncology Qinghua Lian Samuel Yamshon Sherif Badawy University of Washington Yago Nieto

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