“Jean-Charles Soria, Senior Vice President and Oncology Therapeutic Area Head at Amgen, shared on LinkedIn:
Early-onset colorectal cancer: a distinct tumor ecosystem?
Stromal enrichment: Younger MSS tumors exhibit an increased stromal-to-epithelial ratio, validated in 712 tumors.
EMT signaling: Increased inferred FN1, GDF, ACTIVIN and SPP1 interactions suggest enhanced tumor–stroma crosstalk.
Transcriptional rewiring: Increased lncRNA expression, including poorly characterized transcripts, was observed in younger MSS tumors.
Genomic landscape: CNA patterns were largely conserved across ages, with a trend toward greater intratumoral heterogeneity (P=0.056).
Therapeutic opportunities: Stromal remodeling and EMT-associated signaling emerge as potential vulnerabilities.”
Title: Insights into early-onset colorectal cancer from a single-nucleus RNA-seq atlas of colorectal cancer across the age continuum
Authors: Caroline B. M. Porter, Shane P. Murphy, Jules Cazaubiel, Toni M. Delorey, Liat Amir-Zilberstein, Orr Ashenberg, Liubou Klindziuk, Elizabeth Andrews, William Tan, Kosuke Matsuda, Atsushi Kondo, Satoko Ugai, Tomotaka Ugai, Shuji Ogino, Emily Finan, Jacques Deguine, Ewa Sicinska, Lauren K. Brais, Jennifer S. Thalappillil, Marios Giannakis, Ramnik J. Xavier, Ana C. Anderson, Kimmie Ng
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