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Jean-Charles Soria: Understanding cancer’s 5-stage evolution wheel
Jean-Charles Soria/LinkedIn
Apr 5, 2025, 07:39

Jean-Charles Soria: Understanding cancer’s 5-stage evolution wheel

Jean-Charles Soria, SVP and Oncology Therapeutic Area Head of Amgen, shared a post on LinkedIn about a paper by Ranjini Bhattacharya et al. published in Cancer Discovery:

“From resisting death to spreading across the body, cancer evolves through sequential stages. Understanding this roadmap is key to designing better therapies. The Hallmarks of Cancer, reimagined as a 5-stage evolution wheel, encompass:

  1. Initiation
  2. Evolvability
  3. Niche Construction
  4. Survival Adaptations
  5. Emergence.”

“The Hallmarks of Cancer as Eco-Evolutionary Processes “

Authors: Ranjini Bhattacharya, Stanislav Avdieiev, Anuraag Bukkuri, Christopher Whelan, Robert Gatenby, Kenneth Tsai, Joel Brown.

Jean-Charles Soria: Understanding cancer’s 5-stage evolution wheel

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Anuraag Bukkuri cancer Christopher Whelan Jean-Charles Soria Joel Brown Kenneth Tsai OncoDaily Oncology Ranjini Bhattacharya Robert Gatenby Stanislav Avdieiev The Hallmarks of Cancer
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