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MRD-Guided Strategy in Myeloma – International Society of Liquid Biopsy
Aug 6, 2025, 08:12

MRD-Guided Strategy in Myeloma – International Society of Liquid Biopsy

International Society of Liquid Biopsy shared a post on X about a recent article by Aurore Perrot et al. published in NEJM:

“MRD-guided strategy in Myeloma

MIDAS Phase 3 trial published in NEJM

Key findings:

In MRD⁻ pts (10⁻⁵), ASCT vs Isa-KRd to no significant difference in MRD⁻ (10⁻⁶) before maintenance

In MRD⁺ pts, tandem ASCT vs single ASCT to no added benefit

MRD status can personalize post-induction therapy — but more is not always better.”

Title: Measurable Residual Disease–Guided Therapy in Newly Diagnosed Myeloma

Authors: Aurore Perrot, Jérôme Lambert, Cyrille Hulin, Andrea Pieragostini, Lionel Karlin, Bertrand Arnulf, Philippe Rey, Laurent Garderet, Margaret Macro, Martine Escoffre-Barbe, Julie Gay, Thomas Chalopin, Romain Gounot, Jean-Marc Schiano, Mohamad Mohty, Xavier Leleu, Salomon Manier, Clara Mariette, Carine Chaleteix, Thorsten Braun, Bernard De Prijck, Hervé Avet-Loiseau, Jean-Yves Mary, Jill Corre, Philippe Moreau, Cyrille Touzeau

Read the Full Article on The New England Journal of Medicine

MRD-Guided Strategy in Myeloma - International Society of Liquid Biopsy

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