Ilyas Sahin, Assistant Professor at Harvard Medical School, shared on X:
“Can we stop lung cancer before it becomes invasive?
A new Nature study found a network of immune cells called eTregs in high-grade precancerous airway lesions, and showed it can also be tracked in blood. In people with early lung cancer found through screening, stronger eTreg signals were linked to earlier recurrence.
In mice, blocking PI3Kδ disrupted this network and reduced tumor development and size. A promising step toward catching and treating lung cancer earlier, but more research is needed to see whether this works in people.”
Title: A preinvasive regulatory T cell axis for lung cancer interception
Authors: Samuel Gamble, Zoe E. Whiteman, Claudia Peinador-Marín, Marta Lebrusant-Fernandez, Abigail Y. L. Shurr, Andrei Enica, Teerapon Sahwangarrom, Seng Kuong Anakin Ung, Amber Rogers, Petros Fessas, Chuen Ryan Khaw, Lukas Kalinke, Constantin Ahlmann-Eltze, Ahmed S. N. Alhendi, Kate Otter, Xiuchuan Hu, Krupa Thakkar, Betty Gration, Izzy Newsham, Imran Uddin, Ellen Nuttall Musson, Kyren A. Lazarus, Moritz J. Przybilla, Adam Pennycuick, Helen Hall, Zoe Hagel, Charlotte Percival, Ruth Prendecki, Sophie Tisi, Georgia Constantinou, Pascal F. Durrenberger, Kate H. C. Gowers, Yien Ning Sophia Wong, Mark Linch, Kevin Litchfield, Elspeth M. Payne, Se-Hoon Lee, Sergio A. Quezada, Peter J. Campbell, Jennifer E. Beane, Sarah A. Mazzilli, David A. Moore, Vitor H. Teixeira, Sandra Gómez-López, Bart Vanhaesebroeck, Sam M. Janes, James L. Reading.
You can also read: ESMO 2026 Lung Cancer: 10 Abstracts to Watch.
