Ilyas Sahin: Good News in Cancer Screening
Ilyas Sahin, Medical Oncologist at Massachusetts General Hospital, shared a post on X:
“Good news in cancer screening!!!
A new blood test detects early-stage colorectal cancer with 95% accuracy by analyzing RNA modifications—a more stable and sensitive marker than RNA or DNA levels alone.
In a study of 27 CRC patients (including stage 0–I) and 36 matched controls, it captured changes in gut microbial RNA triggered by tumor-related inflammation. Unlike current tests, it reliably detects even the earliest stages.
If validated in larger studies, this approach could become a powerful tool for non-invasive early cancer detection.”
Title: Modifications of microbiome-derived cell-free RNA in plasma discriminates colorectal cancer samples
Authors: Cheng-Wei Ju, Ruitu Lyu, Han Li, Jiangbo Wei, Alberto J. Parra Vitela, Urszula Dougherty, Akushika Kwesi, Alexander Luna, Xuanhao Zhu, Shenghai Shen, Yunzheng Liu, Liangliang Wang, Xiaolong Cui, Yuzhi Xu, Bochen Jiang, Yiyi Ji, Peng Xia, Diana C. West-Szymanski, Chenxi Sun, Yuhao Zhong, Chang Ye, Angelica Moran, Christopher Lehmann, Eric Pamer, Wei Zhang, Marc Bissonnette, Li-Sheng Zhang, Chuan He
Read The Full Article on Nature Biotechnology
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