The Institute of Cancer Research shared on LinkedIn:
“Can studying genetic variants offer new insights into inherited Breast Cancer risk?
Scientists have carried out one of the largest experimental studies of breast cancer variants to date, pinpointing the genetic changes that are most likely to contribute to the development of the disease.
Led by a team in our Division of Breast Cancer Research, the study analysed over 5,000 variants, identifying over 700 across 140 risk regions appearing to alter genetic activity.
One gene – named CCDC88C – emerged as a likely target of a particular risk variant, with its activity linked to oestrogen receptor-positive (ER+) breast cancer.
The findings provide a prioritised list of variants for future investigation and offer new insight into the genetic changes that contribute to inherited breast cancer risk.
‘Our intricate research provides a clearer understanding of the biological pathways involved in breast cancer susceptibility. Particularly CCDC88C’s role in the biology of ER+ breast cancer – contributing to improved risk prediction and potentially unravelling new therapeutic opportunities for patients’ – Senior author Dr Syed Haider.”
More from us here: Scientists pinpoint hundreds of genetic variants that offer new insights into inherited breast cancer risk.”
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