Iannis Aifantis, Chairman of the Department of Pathology at NYU School of Medicine, shared a post on X:
“Excited to share our study on immune interactions in extramedullary (lung) acute myeloid leukemia (AML) out today at Nature Immunology!
Acute respiratory failure frequently occurs in AML due to leukemia infiltration of the lungs. The question is why and what can we do to suppress it.
Varvara Paraskevopoulou in the lab started this work by mapping AML:stromal and AML:immune cell interactions using scRNA-Seq and Visium/Xenium 10x Genomics spatial tools.
We then focused on two inflammatory/immune modulating pathways, IL33:IL1RL1 and LGALS9:GAL9R. The S-type lectin Lgals9 is triggered by inflammation within infiltrated the lungs. The alarmin IL-33 and its receptor (IL-1RL1) are involved in cell–cell interactions within the leukemic lung microenvironment.
Targeting either the Lgals9 or IL-33 axis significantly decreased overall AML burden and lung infiltration through effects on both the immune microenvironment (T cells) and AML cells.
These pathways are clinically important because of antibodies that are available …
- AstraZeneca
IL-33-targeting biologic recently showed benefits in COPD, and, - PureTechH
recently announced positive initial topline data for an Gal9-targeted antibody in AML/MDS.
For us it will be exciting to focus on the mechanism of action of such biologics in our system.”
This study was a long-term collaborative effort with Manel Esteller
and his lab as well as Ak Eisfeld and Sanam Loghavi. Huge thanks to Ziyan Lin, Aristotelis Tsirigos and Papagiannakopoulos Lab.”
Title: Inflammatory immune modulators of AML lung infiltration and respiratory failure
Authors: Varvara Paraskevopoulou, Ziyan Lin, Marta Casado-Pelaez, Daniela Grases, Wafa Al-Santli, Juan Carlos Balandrán, Fang Zhou, Ali Rashidfarrokhi, Michael Cross, Stephen T. Yeung, Konstantinos Ntatsoulis, Tejas Patel, Xufeng Chen, Deedra Nicolet, Marc Escobosa, Eduard Porta, Jennifer J. Trowbridge, Kamal M. Khanna, Thales Papagiannakopoulos, Andre L. Moreira, Rashmi Kanagal-Shamanna, Sanam Loghavi, Aris Tsirigos, Ann-Kathrin Eisfeld, Manel Esteller, Iannis Aifantis
Other articles featuring Iannis Aifantis on OncoDaily.