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Gustavo Viani: Higher radiation in Pediatric Ependymomas – more harm than good?
Gustavo Viani/sbradioterapia.com.br
Feb 5, 2025, 21:31

Gustavo Viani: Higher radiation in Pediatric Ependymomas – more harm than good?

Gustavo Viani, Professor of Radiation Oncology at Ribeirão Preto Medical School, shared a post on X about a paper by Melanie Rose et al. published in the International Journal of Radiation Oncology, Biology, Physics:

“Higher Radiation in Pediatric Ependymomas: More Harm Than Good?

Objective

  • Assess optimal radiation dose (≤54 Gy vs. >54 Gy) for pediatric intracranial ependymomas
  • Evaluate Local Control (LC), Event-Free Survival (EFS), Overall Survival (OS), and toxicity

Methods

  • Meta-analysis of 7 studies (1321 patients)
  • Outcomes: LC, EFS, OS, and late toxicities (necrosis, vasculopathy, cognitive lower)

Results

  • No survival benefit for >54 Gy.
  • Higher doses = more cognitive toxicity

Conclusion

  • ≤54 Gy is effective and may reduce toxicity.
  • Future research needed on molecular subtypes and STR.”

“Systematic Review and Meta-Analysis of Adjuvant Radiation Dose for Pediatric Patients (≤22 years) with Nonmetastatic Intracranial Ependymomas”

Authors: Melanie Rose et al.

Gustavo Viani: Higher radiation in Pediatric Ependymomas - more harm than good?

More posts featuring Gustavo Viani.

cancer Gustavo Viani Melanie Rose OncoDaily Oncology pediatric ependymomas Radiation
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