Gustavo Viani/sbradioterapia.com.br
May 11, 2025, 18:23
Gustavo Viani: New Study on SBRT vs Conventional Radiotherapy for Painful Bone Metastases
Gustavo Viani, Associate Professor at Faculty of Medicine of Ribeirão Preto (FMRP), University of São Paulo (USP), shared a post on X:
“New Study on SBRT vs. Conventional RT for Painful Bone Metastases!
Study Objective
Compare the effectiveness of dose-escalated SBRT (20 Gy) vs. conventional RT (8 Gy) in achieving complete pain response for painful bone metastasesMethods
Design: Phase III RCT, single-blind
Patients: 126 with ≤3 painful bone mets (pain score ≥2/10)
Treatment: SBRT 20 Gy (single fraction) vs. conventional RT 8 Gy (single fraction).
Primary Outcome: Complete pain response at 1 month (International Consensus)
Key Results
1 month: SBRT 37% vs. RT 25% (P = .25)
3 months: SBRT 33% vs. RT 24% (P = .32)
Per-protocol (3 months): SBRT 54% vs. RT 31% (P = .048)
SBRT did not improve complete response rates at 1 month”
Title: Dose-Escalated Stereotactic Versus Conventional Radiotherapy for Painful Bone Metastases (ROBOMET): A Multicenter, Patient-Blinded Randomized Clinical Trial
Authors: Carole Mercier, Charlotte Billiet, Katrien Vandecasteele, Geert De Kerf, Michaël Claessens, Steven Van Laere, Peter Vermeulen, Luc Dirix, Yolande Lievens, Dirk Verellen, Piet Dirix
You can read the Full Article on Journal of Clinical Oncology
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