Gustavo Viani/sbradioterapia.com.br
Feb 6, 2025, 16:30
Gustavo Viani: Do Relapse Patterns Differ Between Hypofractionation and Conventional RT?
Gustavo Viani, Professor of Radiation Oncology at Ribeirão Preto Medical School, shared an article by M.Langé, et al. on X:
“RT in Prostate Cancer: Do Relapse Patterns Differ Between Hypofractionation and Conventional RT?
Objective:
- Compare relapse patterns between HFRT and CFRT in IR PCa.
Methods:
- Post-hoc analysis of 274 (130 HFRT; 144 CFRT) from PROFIT trial.
Treatment:
- HFRT: 60 Gy/20 fr (4 w).
- CFRT: 78 Gy/39 fr (7–8 w).
No ADT allowed.
Follow-up: 6.4 y
Relapse detected by: PSMA PET-CT, choline PET-CT, MRI, bone images.
Results:
- Relapse rate: 23% (HFRT: 24.3%, CFRT: 19.4%).
Time to relapse:
- Local: 4.9y.
- Pelvic nodes: 3.96 y
- Extra-pelvic nodes: 2.95 y
- Bone: 3.6 y
Relapse patterns:
- Extraprostatic: 69% (pelvic/extra-pelvic nodes, bone)
- Intraprostatic only in 31%
- PSA, Roach score, and unfavorable Zumsteg classification predicted relapse.
Treatment at First Relapse:
- ADT: 65% (41/63)
- Salvage pelvic : 25% (16/63)
- Prostate local therapy: 11% (7/63)
Patterns of relapse following radiotherapy of intermediate-risk (IR) prostate cancer (PCa) on the PROFIT randomized trial.
Authors: M. Langé, et al.
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