Grace Meaker, DPhil Medical Sciences Student at the University of Oxford, shared a post on X about a paper she co-authored with colleagues published in Blood:
“Happy to report my PhD findings have now been published as a first edition in Blood!
Here, we used a genome-wide CRISPR screen in haematopoietic stem cells (HSCs) and uncovered novel regulators of expansion to inform clinical applications.
We found that the bone development gene, Runx2, is a potent repressor of HSC expansion. Runx2-deficient HSCs engraft into recipients up to 10-fold more than the wild-type!
We also uncovered a novel role for Runx2 in T-cell commitment.
Thank you to all my co-authors, especially Catherine Chahrour, Matthew Nicholls, and Ian Hsu.
I also must thank my supervisor, Adam Wilkinson, for his expertise, support, and contagious passion for stem cell biology.”
Title: Genome-wide screen identifies Runx2 as a novel regulator of hematopoietic stem cell expansion and T-cell commitment
Authors: Grace A. Meaker, Matthew Nicholls, Catherine Chahrour, Ian Hsu, Alastair Smith, Yavor Bozhilov, Maurice Leung, Hugo Vassort, Leonid Olender, Oliver Beaven, Xinran Huang, Elizabeth J. Brown, Marlies Vanden Bempt, Hwei Minn Khoo, Joydeep Bhadury, Thomas A. Milne, and Adam C. Wilkinson
You can read the Full Article in Blood.
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