Frank Szulzewsky: The Oncogenic Role of TFE3 Domains in YAP1::TFE3 Fusion Tumors
Frank Szulzewsky, Investigator at Huntsman Cancer Institute, shared a post on LinkedIn:
”Our manuscript exploring the impact of TFE3 activity and the different TFE3 domains on the oncogenicity of YAP1::TFE3 just got published in Scientific Reports!
We have previously shown that TEAD-dependent YAP1 activity is pivotal for the oncogenic functions of YAP1 fusions, however, the impact of the C-terminal fusion partner remained understudied. Here we show that TFE3 activity – exerted by the DNA binding basic helix-loop-helix and leucine zipper domains – significantly contributes to the latency and histomorphology of YAP1::TFE3-driven mouse tumors. In addition, we show that the TFE3 activation domain is pivotal for tumor formation. Our findings may have important implications for novel therapies against YAP1::TFE3-fused Epithelioid hemangioendothelioma, a rare cancer for which currently no systemic therapies exist.”
Title: C-terminal fusion partner activity contributes to the oncogenic functions of YAP1::TFE3
Authors: Patrick J Cimino, Dylan J Keiser, Abigail G Parrish, Eric C Holland, Frank Szulzewsky
Read the Full Article.
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