Francesco Iorio, Senior Research Group Leader at Human Technopole, shared a post on LinkedIn:
“Today marks an exciting milestone.
Our Nature Genetics commentary introducing PRECISE is now published.
PRECISE (Predictive Relationships Explaining Cancer Genetic Interactions and Synthetic Essentiality) brings together more than 30 research groups from over 20 institutes across 9 European countries, united by a shared ambition: moving cancer functional genomics beyond mapping vulnerabilities towards predicting them.
Over the past decade, large-scale perturbation screens have transformed our understanding of cancer dependencies and profoundly changed how new therapeutic targets in oncology are discovered and prioritised.
PRECISE aims to build on these foundations by combining perturbation biology, multimodal molecular profiling, AI, and machine learning to learn generalisable rules governing cancer vulnerability and ultimately guide the next generation of experiments and therapeutic discoveries.
It has been a privilege to coordinate the writing of this commentary alongside such an outstanding group of colleagues. What began as two workshops has evolved into a genuinely collaborative European initiative, and I am deeply grateful to everyone who contributed to making PRECISE a reality.
Many thanks to all consortium members.
I hope this is only the beginning.
To learn more about the consortium, its scientific vision, participating groups, and shared resources, visit the PRECISE portal”
Title: The PRECISE European initiative for cancer-vulnerability mapping and prediction
Authors: Francesco Iorio, Mathew J. Garnett, Pedro Beltrao, Maximilian Billmann, Larissa Bless, Christoph Bock, Michael Boutros, Alejandra Bruna, Piero Carninci, Giovanni Ciriello, Isidro Cortés-Ciriano, Giuseppina D’Alessandro, Roberta Esposito, Stefania Faletti, Emanuel Gonçalves, Syed Haider, Nereo Kalebic, Manuel Kaulich, Giuseppe Leuzzi, Nuria Lopez-Bigas, Christopher J. Lord, Evangelia Petsalaki, Stephen Pettitt, Ludovica Proietti, Roland Rad, Nevenka Radic, Colm J. Ryan, Jonathan L. Schmid-Burgk, Sumana Sharma, Andrea Sottoriva, Christopher Tape, Livio Trusolino, Jolanda van Leeuwen, David Walter, Lodewyk Wessels and the PRECISE consortium.
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