Science

Francesca Palandri Highlights Risk Assessment in Myelofibrosis with iRR6 Model

Francesca Palandri/LinkedIn

Aug 26, 2025, 09:26

Francesca Palandri Highlights Risk Assessment in Myelofibrosis with iRR6 Model

Francesca Palandri, Adjunct Professor of Hematology at University of Bologna, shared a post on LinkedIn about a paper published on ACS Journals:

“New Publication in Cancer Journal ‘Revised iRR6 Model in Intermediate-1 Risk Myelofibrosis Patients Treated with Ruxolitinib’

This study builds on the RR6 model, which identifies myelofibrosis patients with poorer overall survival after 6 months of ruxolitinib therapy. Recognizing its limitations in lower-risk groups, we developed and validated the iRR6 model, tailored specifically for intermediate-1 risk patients.

By incorporating new clinical variables – ruxolitinib dosing relative to platelet count, spleen response, and transfusion needs – the iRR6 model offers a refined tool to guide early therapeutic decisions and personalize care for this unique patient population.

Special thanks to Dr. Andrew Kuykendall from the Moffitt Cancer Center for leading the external validation effort and contributing critical insights.

This work was promoted by IRCCS Policlinico di Sant’Orsola – Azienda Ospedaliero Universitaria di Bologna and performed within the framework of the University of Bologna (Alma Mater Studiorum – Università di Bologna).

Grateful to AIL Bologna and to all co-authors for their dedication and insight.”

Title: Revised “iRR6” model in intermediate-1 risk myelofibrosis patients treated with ruxolitinib

Authors: Francesca Palandri, Filippo Branzanti, Massimiliano Bonifacio, Elena M. Elli, Erika Morsia, Mirko Farina, Mario Tiribelli, Giulia Benevolo, Eloise Beggiato, Bruno Martino, Giovanni Caocci, Novella Pugliese, Alessia Tieghi, Monica Crugnola, Gianni Binotto, Francesco Cavazzini, Elisabetta Abruzzese, Alessandro Isidori, Alessandra Dedola, Emilia Scalzulli, Andrea Duminuco, Luca Tosoni, Alda Strazimiri, Roberto M. Lemoli, Daniela Cilloni, Monica Bocchia, Fabrizio Pane, Chiara Sartor, Florian H. Heidel, Massimo Breccia, Giuseppe A. Palumbo, Andrew T. Kuykendall

Francesca Palandri