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Florian Lordick: Important gastric cancer publication from LEGACY consortium connecting Latin America and Europe
Florian Lordick/LinkedIn
Mar 8, 2025, 22:46

Florian Lordick: Important gastric cancer publication from LEGACY consortium connecting Latin America and Europe

Florian Lordick, Professor of Medicine at the University of Leipzig, shared a post on LinkedIn about a paper he co-authored with colleagues published in ESMO Open:

“Important Gastric Cancer publication from the LEGACY consortium connecting Latin America and Europe.

Congratulations to Tania Fleitas Kanonnikoff, Rodrigo Dienstmann, Andres Cervantes, Sarah Derks, Erika Ruiz-Garcia, Maria Alsina, Fatima Carneiro and all cooperating colleagues.

  • GC is highly heterogeneous at clinicopathological and molecular levels.
  • We found major differences in the prevalence of actionable biomarkers across European and LATAM populations.
  • HER2-positive and high PD-L1 are enriched in Europe, while EBV-positive and high TMB are more prevalent in LATAM.
  • Intestinal HER2-negative tumors are enriched for mutations in HRR genes.
  • Diffuse GC have unique microenvironment and pathway activation signature score.”

“Integrated clinico-molecular analysis of gastric cancer in European and Latin American populations: LEGACY project”

Authors: Tania Fleitas, Rodrigo Dienstmann, Andres Cervantes, Sarah Derks, Erika Ruiz-Garcia, Maria Alsina, Fatima Carneiro, Florian Lordick et al.

Florian Lordick: Important gastric cancer publication from LEGACY consortium connecting Latin America and Europe

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Andres Cervantes cancer Erika Ruiz-Garcia Fátima Carneiro Florian Lordick gastric cancer LEGACY project Maria Alsina OncoDaily Oncology Rodrigo Dienstmann Sarah Derks Tania Fleitas
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