Fabio Carbone, Colorectal Surgeon at IRCCS National Cancer Institute G. Pascale Foundation, Naples, Italy, shared on LinkedIn:
“New publication – Article in Press!
I’m pleased to share our latest systematic review and meta-analysis, now available in the World Journal of Surgical Oncology.
This review included 32 studies, with 18 studies and 1,141 patients contributing to the quantitative synthesis, providing the largest ISR-specific synthesis on Low Anterior Resection Syndrome (LARS) after intersphincteric resection for low and ultralow rectal cancer.
Key findings:
- Major LARS affects nearly one in two patients (46%) after ISR.
- Minor LARS: 25%
- No LARS: 37%
- Lower tumour location, very low anastomosis and neoadjuvant chemoradiotherapy were among the factors most consistently associated with postoperative bowel dysfunction.
These findings highlight the importance of balancing oncological safety, sphincter preservation, and long-term functional outcomes when counselling patients and tailoring treatment strategies.
Title: Low anterior resection syndrome after intersphincteric resection for low and ultralow rectal cancer: a systematic review and meta-analysis with narrative synthesis of reported factors
Authors: Mohammadsadra Shamohammadi, Sana Ehsan Ullah, Marina Yiasemidou, Mansour Bahrdoust, Armaghan Abbasi Garavand, Danyal Yarahmadi, Fabio Carbone
A special thank you to Mohammadsadra Shamohammadi for his outstanding work, dedication and commitment throughout this project. It has been a pleasure to contribute.
My sincere thanks also to Sana Ehsan Ullah, Marina Yiasemidou, Mansour Bahrdoust, Armaghan Abbasi Garavand, and Danyal Yarahmadi for their valuable collaboration.”
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