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Eric Topol: A new mechanism for cancer-induced immune evasion
Jan 25, 2025, 12:41

Eric Topol: A new mechanism for cancer-induced immune evasion

Eric Topol, Founder and Director of Scripps Research Translational Institute at The Scripps Research Institute, shared two recent articles on X:

“A new mechanism for cancer-induced immune evasion.

We knew about cancer cells hijacking mitochondria. Now we learn about how their mitochondrial transfer to T cells impairs the tumor immune response.”

Immune evasion through mitochondrial transfer in the tumour microenvironment

Authors: Hideki Ikeda, Katsushige Kawase, Tatsuya Nishi, Tomofumi Watanabe, Keizo Takenaga, Takashi Inozume, Takamasa Ishino, Sho Aki, Jason Lin, Shusuke Kawashima, Joji Nagasaki, Youki Ueda, Shinichiro Suzuki, Hideki Makinoshima, Makiko Itami, Yuki Nakamura, Yasutoshi Tatsumi, Yusuke Suenaga, Takao Morinaga, Akiko Honobe-Tabuchi, Takehiro Ohnuma, Tatsuyoshi Kawamura, Yoshiyasu Umeda, Yasuhiro Nakamura, Yukiko Kiniwa, Eiki Ichihara, Hidetoshi Hayashi, Jun-ichiro Ikeda, Toyoyuki Hanazawa, Shinichi Toyooka, Hiroyuki Mano, Takuji Suzuki, Tsuyoshi Osawa, Masahito Kawazu and Yosuke Togashi

Eric Topol

Eric Topol: A new mechanism for cancer-induced immune evasion

Mitochondrial swap from cancer to immune cells thwarts anti-tumour defences

Author: Jonathan R. Brestoff

Eric Topol

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