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Eric Singhi: Phase 1a study of zongertinib in metastatic solid tumors with HER2 alterations
Eric Singhi/faculty.mdanderson.org
Mar 5, 2025, 16:21

Eric Singhi: Phase 1a study of zongertinib in metastatic solid tumors with HER2 alterations

Eric Singhi, Assistant Professor in the Department of General Oncology at The University of Texas MD Anderson Cancer Center, shared a post on X about a paper by John Heymach et al. published in the Journal of Clinical Oncology:

“Out in Journal of Clinical Oncology – Phase 1a study of zongertinib in metastatic solid tumors with HER2 alterations:

  • 54 NSCLC patients
  • ORR 35%, DCR 93%
  • PFS 17.2 mos
  • Diarrhea most common AE (50%, most grade 1/2)
  • Expansion doses: 120/240mg QD

Timely as U.S. FDA granted priority review <2 weeks ago!”

“HER2-Selective Tyrosine Kinase Inhibitor, Zongertinib (BI 1810631), in Patients With Advanced/Metastatic Solid Tumors With HER2 Alterations: A Phase Ia Dose-Escalation Study

Authors: John Heymach, Frans Opdam, Minal Barve, Kiyotaka Yoh, Noboru Yamamoto et al.

Eric Singhi: Phase 1a study of zongertinib in metastatic solid tumors with HER2 alterations

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cancer Eric Singhi Frans Opdam John Heymach Kiyotaka Yoh Minal Barve Noboru Yamamoto OncoDaily Oncology solid tumors Zongertinib
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