Enrique Grande, Adjunct Professor at The University of Texas MD Anderson Cancer Center, shared on X:
“On Nature Medicine – Urine cell-free RNA profiling (uRARE-seq) for bladder cancer detection and treatment response prediction (n=683 samples).
95% sensitivity at 90% specificity for localized BLCA – outperforming cytology and urine tumor DNA. Also predicts response to BCG vs intravesical chemotherapy (AUC 0.93).”
Title: Urine cell-free RNA for bladder cancer detection and treatment response prediction
Authors: Kevin J. Liu, William Y. Shi, Monica C. Nesselbush, Nick A. Phillips, Kathleen E. Mach, Bogdan Luca, Ravi K. Bajpai, Isabel Jabara, Jordan C. Cheng, Takeshi Sugio, Navika Shukla, Emily C. Shen, Ivy Lee Koh, Douglas J. Wu, Chih-Long Liu, Diego Almanza, Soyeong Jun, Feng Tian, Emily G. Hamilton, Christian R. Hoerner, Rui Wang, Mohammad S. Esfahani, Angela Hui, Vinh La, Grace Holton, Gabriela Rodriguez, Timothy J. Lee, Xi Ling, Nikitha Kalahasti, Spoorthi Vallamkonda, Patrick Mullane, Simon B. Chen, Eugene Shkolyar, Kris Prado, Ali Raza Khaki, Emily Chan, Mark K. Buyyounouski, Alice C. Fan, Eila C. Skinner, Ash A. Alizadeh, Joseph C. Liao, Maximilian Diehn
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