Donald McDonnell: The mechanisms by which estrogens manifest immunosuppressive activity
Donald McDonnell, Professor at the Department of Pharmacology and Cancer Biology at Duke University School of Medicine, shared a post on LinkedIn, about a paper by him and colleagues, published in BioRxiv.
“In previously published work from our laboratory Dr. Binita Chakraborty demonstrated that estrogens, acting through the estrogen receptor (ER) in tumor-associated macrophages, attenuate tumor immunity.
In this follow-up study she has defined the mechanisms by which estrogens manifest this immunosuppressive activity-work that highlights the potential clinical utility of Selective Estrogen Receptor Modulators (SERMs) and Selective Estrogen Receptor Downregulators (SERDs) beyond luminal breast cancer where they are currently used.”
Authors: Binita Chakraborty, Prabuddha Chakraborty, Michael Brown, Ching-Yi Chang, Donald McDonnell et al.
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