Cristiane Bergerot, Former Postdoc Fellow and Research Consultant at City of Hope, shared several interesting articles from JCO Oncology Advances on X:
“Adding carboplatin to neoadjuvant chemotherapy improves pathologic response and event-free survival in early-stage TNBC, while immune signatures provide additional prognostic insights.”
Title: Impact of Neoadjuvant Carboplatin in Early-Stage Triple-Negative Breast Cancer: A Pooled Analysis of the BrighTNess, Cancer and Leukemia Group B 40603 (Alliance), and GeparSixto Clinical Trials
Authors: Brooke M. Felsheim, Jens Huober, Lisa A. Carey, Valentina Nekljudova, Thomas Karn, Sara M. Tolaney, Andreas Schneeweiss, Michael Untch, Christoph Salat, Charles S. Kuzma, Aranzazu Fernandez-Martinez, Sivaramakrishna Rachakonda, Jose J. Ponce-Lorenzo, Dirk-Michael Zahm, Rama Suresh, Daniel G. Stover, Priya Rastogi, Maren Darsow, Diana E. Lake, Hope S. Rugo, Joyce O’Shaughnessy, Mehra Golshan, Adam D. Pfefferle, William M. Sikov, Otto Metzger, Carsten Denkert, Charles E. Geyer, Charles M. Perou, Sibylle Loibl.
Read the full article.
“Dual LAG-3/PD-1 blockade did not improve survival in PD-L1-positive MSS/pMMR metastatic colorectal cancer, highlighting the need for alternative immunotherapy strategies.”
Title: Favezelimab/Pembrolizumab Coformulation Versus Standard-of-Care in PD-L1–Positive Metastatic Colorectal Cancer: The Phase III, Randomized KEYFORM-007 Study
Authors: Neil Howard Segal, Maria Passhak, Fatih Köse, Elena Elez, Hisato Kawakami, Marianne G. Guren, Derek Jonker,
Rui-Hua Xu, Jorge Riera Knorrenschild, Yu-Min Yeh, Mastura Yusof, Kai Keen Shiu, Naureen Starling, Xiang Peng, David R. Fogelman, David Adelberg, Tae Won Kim.
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“Less bureaucracy, more efficient and patient-centered clinical research, without compromising safety or data integrity.”
Title: ESMO and ASCO Consensus on Good Clinical Practice Guideline E6(R3): A Step Forward Towards Streamlining Clinical Research
Authors: Jose Luis Perez-Gracia, Laura Levit, Miguel F. Sanmamed, Priyanka Sharma, Fabrice André, Christian Hosius, Binita Patel, Alessandra Nuti, Lisa Carey, Teresa Amaral.
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“Combining patient-centered design and implementation science offers a promising approach to supporting informed consent and shared decision-making in prostate cancer germline testing.”
Title: Developing an Intervention to Improve Informed Decision Making in Veterans With Prostate Cancer Considering Germline Testing With Their Oncologist: A Mixed-Methods Study
Authors: Daniel H. Kwon, Maren T. Scheuner, Alondra Camarena, Marissa McPhaul, Saffanat Sumra, Eliza L. Hearst, Carling Ursem, Evan Walker, Sunny Wang, Franklin W. Huang, Rahul R. Aggarwal, Jeff Belkora.
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“Oxaloacetate showed promising preliminary results for cancer-related cognitive impairment, supporting further investigation in randomized, placebo-controlled trials to establish efficacy.”
Title: Results From a Phase II Single-Arm Trial Evaluating the Safety and Efficacy of Anhydrous Enol-Oxaloacetate on Improving Cognitive Complaints in Breast Cancer Survivors
Authors: Patricia A. Ganz, Kathleen Van Dyk, Catherine M. Crespi, Laura Petersen, Mina S. Sedrak, Julienne E. Bower.
Read the full article.
Other articles from JCO Oncology Advances on OncoDaily.