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Katy Rezvani: CREM As a Key Checkpoint Limiting CAR NK Cell Function

Katy Rezvani/LinkedIn

Jun 5, 2025, 15:44

Katy Rezvani: CREM As a Key Checkpoint Limiting CAR NK Cell Function

Katy Rezvani, Vice President and Head of Institute for Cell Therapy Discovery and Innovation at MD Anderson Cancer Center, shared a post on LinkedIn:

“Please check out our paper published in Nature that identifies CREM as a key checkpoint limiting CAR NK cell function.

We show that CRISPR knockout of CREM significantly enhanced anti-tumor activity, implicating a broader role in NK and T cell regulation.

Huge congrats to Hind Rafei and our incredible collaborators whose hard work made this possible.

Excited to explore the translation of this approach to the clinic.”

Title: CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells

Authors: Hind Rafei, Rafet Basar, Sunil Acharya, Yu-Sung Hsu, Pinghua Liu, Deqiang Zhang, Toszka Bohn, Qingnan Liang, Vakul Mohanty, Ranjan Upadhyay, Ping Li, Pravin Phadatare, Merve Dede, Donghai Xiong, Huihui Fan, Corry Mathew Jones, Sebastian Kunz, May Daher, Ana Karen Nunez Cortes, Mayra Shanley, Bin Liu, Sadie Mae Moseley, Chenyu Zhang, Dexing Fang, Pinaki Banerjee, Nadima Uprety, Ye Li, Rejeena Shrestha, Xinhai Wan, Hong Shen, Vernikka Woods, April Lamour Gilbert, Seema Rawal, Jinzhuang Dou, Yukun Tan, Jeong-Min Park, Francia Reyes Silva, Alexander Biederstädt, Mecit Kaplan, Xin Ru Jiang, Inci Biederstädt, Bijender Kumar, Silvia Tiberti, Madison Moore, Jingling Jin, Ryan Z. Yang, Luis Muniz-Feliciano, Samuel Rosemore, Paul Lin, Gary M. Deyter, Natalie Wall Fowlkes, Abhinav K. Jain, David Marin, Anirban Maitra, Ken Chen, Tobias Bopp, Elizabeth J. Shpall, Katayoun Rezvani

You can read the Full Article on Nature.

Katy Rezvani: CREM As a Key Checkpoint Limiting CAR NK Cell Function

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Katy Rezvani: CREM As a Key Checkpoint Limiting CAR NK Cell Function

“Please check out our paper published in Nature that identifies CREM as a key checkpoint limiting CAR NK cell function.

We show that CRISPR knockout of CREM significantly enhanced anti-tumor activity, implicating a broader role in NK and T cell regulation.

Huge congrats to Hind Rafei and our incredible collaborators whose hard work made this possible.

Excited to explore the translation of this approach to the clinic.”