Science

Feb 25, 2025, 10:52

Liquid Biopsy in Clinical Practice: Past, Present and Future – ISLB

International Society of Liquid Biopsy shared an article by Jinghan Song, et al. on X:

“Liquid Biopsy in Clinical Practice: Past, Present & Future.

A new review explores the evolution, applications, and future directions of liquid biopsy in oncology. Here are the key insights:

Technologies & Biomarkers:

Circulating Tumor Cells (CTCs) – Enrichment & detection methods (PCR, IHC, FISH, scRNA-seq).
Circulating Tumor DNA (ctDNA) – PCR & NGS-based detection for genomic alterations.
Exosomes – Advanced methods for isolating tumor-derived extracellular vesicles.

Clinical Applications:

Early Cancer Detection – Liquid biopsy enhances non-invasive screening.
Cancer Staging & Prognosis – Stratifies patients based on risk & molecular profiling.
Therapy Guidance – Detects actionable mutations like ESR1, PIK3CA, EGFR, ALK for precision medicine.
Treatment Response Monitoring – Tracks minimal residual disease (MRD) & therapy resistance.

Advancing Liquid Biopsy for Multi-Cancer Screening.

Emerging multi-cancer detection technologies: CCGA3, CancerSEEK, THUNDER, DETECT-A, PATHFINDER.
AI & machine learning integration for enhanced diagnostic accuracy.

Future Directions:

Standardization & Validation – Steps to clinical utility.
Multi-Omics Approach – Integrating genomics, transcriptomics, and proteomics.
Ex Vivo Models – Using CDX mouse models for precision therapy testing.

Liquid biopsy is revolutionizing oncology—enhancing early detection, personalized treatment & real-time monitoring.

Read the full study.”

Liquid Biopsy in Clinical Practice: Past, Present and Future - ISLB

Liquid biopsy entering clinical practice: Past discoveries, current insights, and future innovations.

Authors: Jinghan Song, et al.

Liquid Biopsy in Clinical Practice: Past, Present and Future - ISLB

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