
Feb 25, 2025, 10:52
Liquid Biopsy in Clinical Practice: Past, Present and Future – ISLB
International Society of Liquid Biopsy shared an article by Jinghan Song, et al. on X:
“Liquid Biopsy in Clinical Practice: Past, Present & Future.
A new review explores the evolution, applications, and future directions of liquid biopsy in oncology. Here are the key insights:
Technologies & Biomarkers:
- Circulating Tumor Cells (CTCs) – Enrichment & detection methods (PCR, IHC, FISH, scRNA-seq).
- Circulating Tumor DNA (ctDNA) – PCR & NGS-based detection for genomic alterations.
- Exosomes – Advanced methods for isolating tumor-derived extracellular vesicles.
Clinical Applications:
- Early Cancer Detection – Liquid biopsy enhances non-invasive screening.
- Cancer Staging & Prognosis – Stratifies patients based on risk & molecular profiling.
- Therapy Guidance – Detects actionable mutations like ESR1, PIK3CA, EGFR, ALK for precision medicine.
- Treatment Response Monitoring – Tracks minimal residual disease (MRD) & therapy resistance.
Advancing Liquid Biopsy for Multi-Cancer Screening.
- Emerging multi-cancer detection technologies: CCGA3, CancerSEEK, THUNDER, DETECT-A, PATHFINDER.
- AI & machine learning integration for enhanced diagnostic accuracy.
Future Directions:
- Standardization & Validation – Steps to clinical utility.
- Multi-Omics Approach – Integrating genomics, transcriptomics, and proteomics.
- Ex Vivo Models – Using CDX mouse models for precision therapy testing.
Liquid biopsy is revolutionizing oncology—enhancing early detection, personalized treatment & real-time monitoring.
Read the full study.”
Liquid biopsy entering clinical practice: Past discoveries, current insights, and future innovations.
Authors: Jinghan Song, et al.
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